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Demerol (meperidine) is an opioid analgesic historically used for moderate to severe pain. Due to safety concerns—including the risk of neurotoxicity from its metabolite (normeperidine), especially with repeated dosing or kidney impairment—its use has declined in many clinical settings. Healthcare providers carefully assess pain severity, patient history, kidney function, and potential drug interactions before prescribing. It is typically reserved for short-term use when alternative options are not appropriate.
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